This organic chemistry video tutorial provides the mechanism of the E1 and E2 dehydrohalogenation of alkyl halides or haloalkanes to form alkenes and the dehydrohalogenation reaction of vicinal dihalides and geminal dihalides to form terminal alkynes and internal alkynes using KOH fused at 200C and NaNH2 at 150C followed by water. This video discusses the formation of the zaitsev / saytzeff major product using a strong unhindered base such as NaOH and the formation of the hoffman product using a bulky strong base such as potassium tert butoxide. In addition, the stereochemistry of the E2 reaction was discussed in terms of its anti-coplanar requirement. The isomerization reaction mechanism of terminal and internal alkynes was also mentioned as well the mechanism of the E1 reaction. Examples and E1 practice problems included carbocation rearrangements such as the hydride shift, methyl shift, and ring expansion. The dehalogenation reaction of vicinal dibromides using NaI in acetone and Zn with CH3COOH to form alkenes was also mentioned.
This organic chemistry video tutorial provides the mechanism of the E1 and E2 dehydrohalogenation of alkyl halides or haloalkanes to form alkenes and the dehydrohalogenation reaction of vicinal dihalides and geminal dihalides to form terminal alkynes and internal alkynes using KOH fused at 200C and NaNH2 at 150C followed by water. This video discusses the formation of the zaitsev / saytzeff major product using a strong unhindered base such as NaOH and the formation of the hoffman product using a bulky strong base such as potassium tert butoxide. In addition, the stereochemistry of the E2 reaction was discussed in terms of its anti-coplanar requirement. The isomerization reaction mechanism of terminal and internal alkynes was also mentioned as well the mechanism of the E1 reaction. Examples and E1 practice problems included carbocation rearrangements such as the hydride shift, methyl shift, and ring expansion. The dehalogenation reaction of vicinal dibromides using NaI in acetone and Zn with CH3COOH to form alkenes was also mentioned.
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